West Ham will be without Michail Antonio for the visit of Manchester United.
The striker is suspended following his red card at Southampton last weekend so Jarrod Bowen could move into a central attacking role.
Vladimir Coufal, Angelo Ogbonna and Said Benrahma should return after being rested for Thursday's Europa League win against Dinamo Zagreb.
Manchester United will again be with without Edinson Cavani as he continues to battle a muscle strain.
The Uruguay striker could return to main first-team training next week, but will definitely miss the West Ham trip.
Aaron Wan-Bissaka is free to feature as his Champions League suspension does not extend to the Premier League.
How to follow
West Ham vs Man Utd is live on Sky Sports Premier League, Bein Sports, Super Sports from 1pm; kick-off 2pm.