Manchester United captain Harry Maguire will miss the Everton clash.
Maguire missed Wednesday's Champions League win over Villarreal with a calf injury sustained in last weekend's league defeat to Aston Villa, and manager Ole Gunnar Solskjaer has revealed the centre-back will be out for a few weeks.
Luke Shaw was also forced off injured against Villa and is a doubt for Saturday's early kick-off, but United have been boosted by Marcus Rashford's return to training after underdoing surgery, though he remains several weeks away from full fitness.
Everton will again be without Dominic Calvert-Lewin and Seamus Coleman for the trip to Old Trafford. Striker Calvert-Lewin and skipper Coleman have been recovering from quadriceps and hamstring issues respectively.
Everton also still have Richarlison (knee), Andre Gomes (calf) and Fabian Delph (shoulder) unavailable, while Rafa Benitez revealed Alex Iwobi was a doubt for Saturday's match due to "a little problem".
Jean-Philippe Gbamin can be called upon again following a quadriceps injury.
How to Watch
Follow Man Utd vs Everton on Sky Sports, Bein Sports, Super Sports at 5.15pm from Saturday.